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Pathogenesis

A novel immunomodulatory mechanism uncovered in clear cell RCC

A novel immunomodulatory mechanism uncovered in clear cell RCC

Researchers have uncovered a novel immunomodulatory mechanism in clear cell renal cell carcinoma (ccRCC). The discovery centers on the role of an immune complex, called C1, which is made up of components contributed by macrophages and tumor cells. A genetic study suggested that its presence and biochemical activity may be associated with worse prognoses in patients.

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PD-L1 expression varies dramatically within ccRCC tumors

PD-L1 expression varies dramatically within ccRCC tumors

PD-L1 expression levels vary dramatically within clear cell renal cell carcinoma (ccRCC) tumors, according to reevaluation of ccRCC samples surgically removed during radical nephrectomy.

Furthermore, PD-L1 expression in the tumor and nonexpression in thrombus-associated samples is linked to aggressive behavior in ccRCC, researchers reported in Annals of Diagnostic Pathology.

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